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AH-DB (Apo and Holo structures DataBase) collects apo and holo structure pairs of proteins. Various protein functions have ben shown directly associated with conformational transitions triggered by binding other molecules. Tertiary structures determined in the unbound and bound state are usually named apo and holo structures, respectively.

AH-DB is the largest database of apo-holo strcture pairs and provide a sophisticated interface to search and view the collected data. It contains 746314 apo-holo pairs of 3638 proteins from 702 organisms. See more detailed statistics.

This video contains a brief introduction about AH-DB and why we have created AH-DB, which stands for Apo-Holo Database.

This video shows how to use AH-DB and generally what everything listed on the site means.

Retrieve a session

Session ID

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Search samples


AH-DB covers 715 organisms, where the 20 organisms with the most proteins are shown here (detailed statistics). note

Target protein

Ex: KAD_ECOLI, 4AKE:A or adenylate kinase. Multiple keywords with AND/OR operators are allowed. See more detailed usage.

Added molecules

Ex: BAB, amidin, Cu, copper or those in the Target protein field. See more detailed usage. The checkboxs limit added molecules including/excluding the specified molecule types. The option will be ignored if both inclusion and exclusion checkboxes are checked for the same molecule type.


, where the note

(default list)

How to cite AH-DB

Darby Tien-Hao Chang, Tsung-Ju Yao, Chen-Yu Fan, Chih-Yun Chiang and Yi-Han Bai, "AH-DB: collecting protein structure pairs before and after binding", Nucleic Acids Research (2012) 40 (D1): D472-D478.